The conversation around GLP-1 and GIP/GLP-1 medications has shifted dramatically in recent years. No longer just a buzzword among endocrinologists and obesity specialists, drugs like Zepbound® (tirzepatide) are now front-and-center in the public dialogue on weight management. But do the results last? A new long-term study says yes.
The Breakthrough: A 3-Year Study on Zepbound®
Presented at the 2025 European Congress on Obesity, the latest data on Zepbound revealed sustained weight loss over a remarkable three-year period in adults without type 2 diabetes. In this population, where weight loss is often difficult to maintain, Zepbound demonstrated the potential for long-term metabolic improvement.
What the Numbers Show
Participants receiving tirzepatide lost an average of 26.6% of their body weight over 88 weeks. But the real headline? Most of that weight stayed off over the next 12+ months of continued treatment. Even more impressive, participants reported sustained improvements in waist circumference, blood pressure, and lipid levels—factors that impact both health outcomes and insurance premiums.
Why This Matters
For patients who have struggled with repeated weight gain, this study provides hope. Weight loss isn’t just about looking better—it’s about reducing risk for heart disease, joint degeneration, sleep apnea, and certain cancers. And with the cost of chronic disease skyrocketing in the U.S., sustained weight loss can reduce dependency on medications and health services.
Zepbound vs. Other GLP-1s
Unlike first-generation GLP-1s like Ozempic® and Rybelsus® (semaglutide), Zepbound® combines GIP and GLP-1 receptor agonism, which may help regulate appetite and insulin resistance more effectively. This dual action may be responsible for the more durable weight loss effects seen in this study.
How Achieve Health & Weight Loss Can Help
At Achieve Health and Weight Loss, we integrate evidence-based medications like Zepbound into a comprehensive medical weight management program. Our patients receive:
- Board-certified physician oversight
- Medication monitoring and titration
- A remotely monitored smart scale
- Bi-monthly coaching
- Nutrition and behavior tracking
Is Zepbound® Right for You?
If you’re struggling to maintain weight loss, you’re not alone. Zepbound® offers a powerful, science-backed solution—but it’s most effective when combined with medical oversight and lifestyle support. Our team at Achieve is here to guide you.
Ready to break the cycle and finally keep the weight off?
🚀 Start your journey with Achieve Health and Weight Loss today
