With these medications, you will slowly work your way up to the target dose at which time you will see the most amount of weight loss. This was the case in clinical trials, where participants had their dose adjusted until they reached maximum dose injected once weekly. In the GLP-1 phase 3 trial that measured outcomes at 20 weeks, most participants were able to reach the full dose and also lost weight as their dose was increased. They saw additional weight loss over the remaining 48 weeks at the full dose. It is important to keep in mind that weight loss can take time, and you’ll see the best results when you are using your medication in combination with a medically supervised program, a healthy diet and exercise. Sometimes the medication may not work for you, or you may not be able to tolerate the full dose due to side effects.